Endocrine Abstracts

Objective: To describe body-composition, lipid profile, and health-related quality of life (HRQL) in patients with traumatic brain injury (TBI) in relation to the development of posttraumatic hypopituitarism.Design: Cross-sectional with a nested prospective sub-study.Patients: The cross-sectional cohort included 104 hospitalized patients with TBI (26F/78M; age: median 41 years (range 18–64); BMI: 25 kg/m2 (17–3...

Objective: Vitamin D has potential immunomodulatory effects. We studied whether vitamin D3 supplementation affects the course of Graves’ disease (GD).Methods: In a double-blind, placebo-controlled design, we randomized patients with a first time diagnosis of GD hyperthyroidism to daily supplementation with vitamin D3 70 mg (2800 IU) or placebo, as add-on to standard treatment with anti-thyroid drugs (ATD). The intervention was continued 12 months af...

Background: Secondary adrenal insufficiency is usually treated with hydrocortisone replacement therapy twice or thrice daily in varying doses to mimic the physiological rhythm of cortisol release. However, despite efforts to optimize treatment regimens patients report impaired quality of life (QoL), including important aspects such as fatigue. A possible explanation is a suboptimal imitation of cortisol release resulting in an inadequate substitution at certain times during th...

Introduction: Thyroid disorders have significant impact on patients’ quality of life (QoL). ThyPRO is a thyroid-specific QoL questionnaire applicable to patients with benign thyroid disorders. There is substantial evidence for its clinical validity and reliability in patients with benign thyroid disorders. ThyPRO consists of 85 questions summarized in 13 scales, measuring aspects of QoL relevant to thyroid patients. Our aim was to develop a validated Polish version of thi...

Background: Vitamin D is important to skeletal health and is standard care in conditions with low BMD. Thyrotoxicosis caused by Graves’ disease (GD) leads to increased bone turnover and reduced BMD. We aimed to test the hypothesis that vitamin D supplementation would improve bone recovery in GD.Methods: Using a double-blinded design, hyperthyroid patients with a first time diagnosis of GD were randomized to supplementation with vitamin D3 70 mg/day...

Background: Replicating the physiological cortisol secretion is key in treatment of glucocorticoid insufficient individuals. A sub-optimal replication may explain the impaired quality of life experienced by these individuals. The study investigates fatigue measured by ecological momentary assessments in patients treated with conventional hydrocortisone compared with a once-daily dual-release formula of hydrocortisone (Plenadren) that follows the cortisol physiology more closel...

Background: Vitamin D deficiency has been proposed to play a role in development and course of Graves’ disease (GD). Muscle weakness and fatigue are shared features of GD and vitamin D deficiency. We aimed to investigate whether vitamin D supplementation would improve restoration of muscle performance and thyroid-related quality of life (QoL) in GD.Methods: In a double-blinded clinical trial, hyperthyroid patients with a first time diagnosis of GD w...

Background: Risk of cardiovascular disease (CVD) and mortality is increased in Graves’ disease (GD) even years after initial diagnosis and treatment. The mechanisms are incompletely understood. Vitamin D insufficiency is associated with an increased risk of CVD and has been reported to occur frequently in GD. Pulse wave velocity (PWV) and blood pressure (BP) are important predictors of CVD. We performed a clinical trial, testing whether vitamin D supplementation affects P...

Objectives: Quality of life (QoL) is severely affected in Graves’ disease (GD) but long-term longitudinal assessment of QoL is lacking. Furthermore, whether QoL is comparable to controls after treatment of GD is unclear. For the first time, we present serial, longitudinal data on thyroid-related QoL during 24 months of follow-up in a cohort of newly diagnosed GD patients. In addition, we compare QoL in GD and controls.Methods: All patients were tre...

Objective: Thyroid diseases have been shown to affect quality of life. A thyroid-specific patient-reported outcome (PRO) measuring quality of life, the ThyPRO, has recently been developed and validated using classical clinic- and psycho-metric methods. The purpose of the present study was to apply modern psychometrics to validate the measure as the extent of differential item functioning (DIF) according to sex, age, education and diagnosis, within the ThyPRO.<p class="abst...